Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 2nd International Conference on Autism Phoenix, Arizona,USA.

Day 2 :

Conference Series Autism 2016 International Conference Keynote Speaker Aleida Lanza photo
Biography:

Aleida Lanza is a CoFounder of Zoelogix, parent company of Autism-U.  Along with her partners, including Debora L. Safko, BCBA, Aleida co-developed the world’s first and only artificially intelligent applied behavior analyst to democratize access to evidence-based behavioral health treatment and scale parity.  Aleida’s background as an electronic discovery and litigation support specialist helped to navigate the complexitiesin embedding interoperability.  She is an advocate dedicated to protecting the rights of  individuals with disabilities, previously served as Advocacy Chair for Autism Speaks South Florida Chapter, and continues her advocacy work to embed inclusion standards in healthcare, education, corrections, and business industries.

Abstract:

The need to scale access to parity is clear, now more than ever because it is no longer theory.  Parity has been reduced to code smart enough to enable self-directed treatment, and embeddable in every process across environments.  The answer to the need for parity is an artificially intelligent applied behavior analyst, to which you are now introduced.

 

We have spent a billion dollars in autism research and have learned that the primary treatment remains the same: unattainable to most in need.  Few are aware that a Federal court order precipitated CMS requiring states to cover Applied Behavior Analysis (“ABA”) for individuals with autism until they are 22.  This court order also ruled that withholding ABA from an individual with autism causes irreparable harm. 

 

The American Medical Association then revised its policy urging better access to behavior services in schools, while the U.S. Department of Education ignores the needs of its students with autism when more than half of U.S. states consistently fail IDEA requirements meant to protect our most vulnerable.  Instead, they abdicate intervention and criminalize the need for services they refuse to provide, violating the civil rights of most students with autism as standard operating procedure.

 

The American Academy of Pediatrics and the Centers for Disease Control has identified Applied Behavior Analysis (“ABA”) as the first-line treatment for autism spectrum disorder.  While the treatment rate remains at an average of 1:308 in the United States, nothing is done to bridge the gap in services. This deplorable statistic predicts a Trillion dollars in spending over the next ten years, and no plan to mitigate it.  Our nation’s current health and education policies work to disenfranchise 99% of the affected population from the primary treatment for their condition. 

 

Today, for the first time in history, anyone can go online and access ABA in the presence or absence of a clinician, and produce clinical treatment, analysis, and reporting that is consistent with current clinical standards. 

 

Democratized access to health will predict better outcomes, and you’re invited to join the Parity Project in your efforts to better serve your communities.  Let’s ensure every individual with autism has access to the first-line treatment: ABA.

 

Conference Series Autism 2016 International Conference Keynote Speaker Aleida Lanza photo
Biography:

Aleida Lanza is a CoFounder of Zoelogix, parent company of Autism-U.  Along with her partners, including Debora L. Safko, BCBA, Aleida co-developed the world’s first and only artificially intelligent applied behavior analyst to democratize access to evidence-based behavioral health treatment and scale parity.  Aleida’s background as an electronic discovery and litigation support specialist helped to navigate the complexitiesin embedding interoperability.  She is an advocate dedicated to protecting the rights of  individuals with disabilities, previously served as Advocacy Chair for Autism Speaks South Florida Chapter, and continues her advocacy work to embed inclusion standards in healthcare, education, corrections, and business industries.

Abstract:

The need to scale access to parity is clear, now more than ever because it is no longer theory.  Parity has been reduced to code smart enough to enable self-directed treatment, and embeddable in every process across environments.  The answer to the need for parity is an artificially intelligent applied behavior analyst, to which you are now introduced.

 

We have spent a billion dollars in autism research and have learned that the primary treatment remains the same: unattainable to most in need.  Few are aware that a Federal court order precipitated CMS requiring states to cover Applied Behavior Analysis (“ABA”) for individuals with autism until they are 22.  This court order also ruled that withholding ABA from an individual with autism causes irreparable harm. 

 

The American Medical Association then revised its policy urging better access to behavior services in schools, while the U.S. Department of Education ignores the needs of its students with autism when more than half of U.S. states consistently fail IDEA requirements meant to protect our most vulnerable.  Instead, they abdicate intervention and criminalize the need for services they refuse to provide, violating the civil rights of most students with autism as standard operating procedure.

 

The American Academy of Pediatrics and the Centers for Disease Control has identified Applied Behavior Analysis (“ABA”) as the first-line treatment for autism spectrum disorder.  While the treatment rate remains at an average of 1:308 in the United States, nothing is done to bridge the gap in services. This deplorable statistic predicts a Trillion dollars in spending over the next ten years, and no plan to mitigate it.  Our nation’s current health and education policies work to disenfranchise 99% of the affected population from the primary treatment for their condition. 

 

Today, for the first time in history, anyone can go online and access ABA in the presence or absence of a clinician, and produce clinical treatment, analysis, and reporting that is consistent with current clinical standards. 

 

Democratized access to health will predict better outcomes, and you’re invited to join the Parity Project in your efforts to better serve your communities.  Let’s ensure every individual with autism has access to the first-line treatment: ABA.

Keynote Forum

Christina Adams

Former National Public Radio commentator and Author, USA

Keynote: The Autism-camel connection: How a mother, a son and a camel helped unify the Autism world and inspire a global industry

Time : 11:00-11:40

Conference Series Autism 2016 International Conference Keynote Speaker Christina Adams photo
Biography:

Christina Adams is an award-winning Media Professional, Researcher, former National Public Radio Commentator and Author of “A Real Boy: A True Story of Autism, Early Intervention and Recovery” (Penguin). After an aerospace PR career, Christina turned to autism after her son was diagnosed, becoming an expert in behavioral, dietary and medical interventions. Finding herself a single mom, she imported frozen Bedouin camel milk with USDA permission and her son got better on it overnight. She’s written a medical journal article and consults with doctors and scientists. She’s created a global network of health-seeking families, farmers and camel professionals. Regarding her media coverage, Christina and her work have appeared in Global Advances in Health & Medicine, The Washington Post, The Los Angeles Times, CHILD, NPR, GOOD, Web MD, The Kingsport Times-News, Orange County Register, Autism File, WebMD, National Public Television, Gulf News, Dubai One TV, Khaleej Times, KUCI, My Autistic Muslim Child & more.

Abstract:

 

With camel milk trending in the Huffington Post, Christina Adams MFA, an international speaker with a compelling personal story, is available; “The unofficial spokesperson for camel milk” Good magazine. Since author Christina Adams began investigating camel milk for her son in 2005, increasing evidence of its usefulness as an autism dietary intervention and scientific properties for diseases like diabetes, food allergies and more have emerged. Camel milk is a non-invasive, natural and accessible dietary intervention that appeals to families. Camel milk has become a global parent portal to autism treatment and awareness, as families in the early stages of autism read Adams’ publications online and connect to her seeking help. The author guides families to resources such as ABA, speech, OT, medical care and parental connections, as seen in UAE, India, Israel, Saudi Arabia and USA (plus Somali and Gypsy communities in the US). The author’s professional publications have inspired the camel milk industry in several countries, creating job growth; a positive and engaging blend of science, unique story and inspiration. The power of positive global change plus parental education and intuition will be emphasized

  • Autism Research: New insights
Location: 1
Speaker

Chair

Alok Sharma

Neuro Gen Brain & Spine Institute, India

Session Introduction

Sarah Crawford

Southern Connecticut State University, USA

Title: The Quantitative Threshold Exposure

Time : 11:40-12:10

Speaker
Biography:

Sarah Crawford received a Master’s Degree in Biochemistry from Princeton University in 1982 and a PhD Degree from the Department of Biochemistry and Biophysics, Columbia University College of Physicians and Surgeons in 1987. She has been affiliated with Southern Connecticut State University for over 20 years and is currently the Full Professor in the Department of Biology where she teaches Genetics and Medical Genetics and directs a research laboratory in cancer biology. In 2013, she was awarded a patent by the US Patent Office for a novel cancer treatment for the brain cancer, glioblastoma.

Abstract:

The Quantitative Threshold Exposure (QTE) hypothesis is a multi-factorial threshold model that accounts for the cumulative effects of risk factor exposure in both the causation of autism spectrum disorder (ASD) and its dramatic increase over the past 30 years. The QTE hypothesis proposes that ASD is triggered by the cumulative effects of high-level exposure to endogenous and environmental factors that act as antigens to impair normal immune system (IS) and associated central nervous system (CNS) functions during critical developmental stages. The quantitative threshold parameters that comprise a cumulative risk for the development of ASD are identified by the assessment of documented epidemiological factors that, in sum, determine the likelihood that ASD will occur as a result of their effects on critically integrated IS and CNS pathways active during prenatal, neo-natal and early childhood brain maturation. The model proposes an explanation for the relationship between critical developmental stages of brain/immune system development in conjunction with the quantitative effects of genetic and environmental risk factors that may interface with these critical developmental windows. This model may be useful even when the individual contributions of specific risk factors cannot be quantified, as it proposes that the combined quantitative level of exposure to risk factors for ASD rather than exposure to any one risk factor per se defines threshold occurrence rates.

 

Speaker
Biography:

Deeba completed her masters in animal sciences, from Department of Zoology, University of Punjab and proceeded for PhD in the area of cell and molecular biology from School of biological sciences in the same university. She graduated in August 2008 continued as research associate in the same department. In 2010, Deeba Noreen Baig joined National institute of Physiological Sciences (NIPS), Okazaki, Japan, as post-doctoral fellow. In NIPS, she was working under direct supervision of Prof. Dr. Ryuichi Shigemoto, who is a renowned scientist in the field of freeze fracture replica plating and electron microscopy. She acquired immuno-histochemistry and confocal microscopy skills there. Keeping in view my interest in the areas of neurosciences and molecular biology, he directed Deeba to Prof. Tanaka Shinji, in University of Tokyo, to whom Deeba learned embryonic in vivo microinjection and electroporation system, which is break through now a days in the field of neuro-molecular biology. On returning to NIPS, Deeba Noreen Baig started working in my previous lab with Prof. Katsuhiko Tabuchi and established in vivo microinjection and electroporation system to generate autism candidate gene transgenic model mice.

In 2012, she was awarded prestigious post-doctoral fellowship from Higher Education commission Pakistan and she joined University of Nebraska Medical Center as foreign post doctoral fellow. In UNMC she has been engaged in Prof. Woo-Yang Kim lab on autism project.

In 2013, she appointed as Assistant Professor in Department of Biological Sciences, Forman Christian College University, Lahore. Here, based on my specialization and expertise she is pursuing research in continuation of autism project in Pakistani population.

Abstract:

 

Neuroligins (NL) and their genetic variants were found to be strongly implicated in the pathophysiology of autistic disorders. Neuroligin-2 (NL2) is a postsynaptic cell adhesion molecule, which is predominantly expressed at inhibitory synapses and required for synapse specification and stabilization. NL2 knockout mice lacking functional NL2 were shown to result in alterations of social behaviors as well as altered inhibitory synaptic transmission, hence modifying the excitation to inhibition balance. Here, we focused on the role of NL2 in the cerebral cortex in the regulation of social behaviors. To this purpose, we designed shRNA system based sh-NL2 construct and injected in lateral ventricles of embryonic brain of mice by in utero electroporation (IUE) to knock down the expression of NL2 at transcriptional level. The effects of NL2 gene silencing were explored by analyzing the expression of NL1 to check impairment in synaptic balance. Our results suggest the synchronization of IUE and shRNA silencing technology proved to be highly successful to determine the effect of local suppression of NL2 in defined compartment cortex of brain. Despite of their confined knockdown of NL2 in the cortex, in vitro studies indicated that it is strongly disturbed normal excitation to inhibition balance. The induced synaptic imbalance in cortex critically appeared in hyperactive stereotypies and impaired social interaction of mice, which are key features of autistic like behavior.

Taesung Park

Seoul National University, Korea

Title: analysis of rare variants using generalized structured component analysis

Time : 12:40-13:10

Speaker
Biography:

Taesung Park has completed his PhD from University of Michigan and visiting fellow/scholar from National Institutes of Health. He is a full Professor of the
department of statistics and the Director of National Creative Research Lab for Bioinformatics and Biostatistics, Seoul National University, Korea. Based on the
experience of statistical researches, he founded this lab to extend his research area to bioinformatics and biostatistics. He has published more than 160 papers
in SCIE journals and served as Associate Editor and Editorial Board Member of international journals such as CSDA, Biometrical Journal, Genetic Epi., and Book
Editor of Biometrics.

Abstract:

Most approaches for rare variants focus mainly on individual gene analysis. However, it has also been recognized that a
majority of biological behaviors manifest from a complex interaction of biological pathway. Although several statistical
methods for pathway-based analyses using rare variants have been proposed to analyze pathways individually, those methods
generally assume that the pathways are independent and do not consider substantial overlapping genes between pathways.
In this paper, we propose a novel statistical approach: a robust pathway-based approach using hierarchical components. The
proposed method uses generalized structural components and analyzes all pathways from the public databases such as Kyoto
Encyclopedia of Genes and Genomes (KEGG) pathway database. To consider the relationship between genes within-pathway,
we use both reflective and formative models. Furthermore, our approach uses ridge-regularized method to reduce the effects
of the overlapping genes between pathways. Evaluation of the method was performed with the simulation data sets as well as
the sequencing data for the phenotype ofautism.

Megan Lawson

Pepperdine University, USA

Title: A Spectrum of Treatments for Autism Spectrum Disorder

Time : 13:40-14:10

Speaker
Biography:

Megan Lawson is a 28-year-old, doctoral candidate at Pepperdine University. She is currently doing an advanced neuropsychology externship at Children’s
Hospital Los Angeles. She is experienced in psychodiagnostic and neuropsychological testing of children, in addition to child therapy. Her dissertation, under Louis
Cozolino, PhD, is an online manual that bridges the gap between ASD testing and treatment recommendation and will be used as a pilot at STAR of CA behavioural
services. Emily Edwards is a 25-year-old clinical psychology doctoral student at Pepperdine University. She is currently a pre-doctoral trainee at the Center for
Autism and Related Disorders conducting psychodyagnostic evaluations. In the future she will be working as an pre-doctoral extern at Children’s Hospital Los
Angeles in the Clinical Trials unit conducting neuropsychological assessments. She is experienced in psychodiagnostic and neuropsychological testing of children.
Leanne Mendoza is a 26-year-old clinical psychology doctoral student at Pepperdine University. She is currently a school-based therapist for elementary school
children and a neuropsychology extern at Kaiser Permanente and Children’s Hospital Los Angeles. She is involved in program evaluation research on mental health
psychoeducation for teachers with disruptive behaviors in the classroom.

Abstract:

With increases in knowledge and changes in perspective, what we know as Autism has been redefined again and again. It
is currently understood as a spectrum of neurodevelopmental disorders that presents in early childhood, predominantly
affecting social and emotional functioning along with repetitive or stereotyped behaviors. Although the ideas that Autism is a
heterogeneous disorder that manifest on a spectrum of severity have been accepted, it is too often conceptualized as a single
illness, this results in suboptimal evaluations and overly general treatment recommendations.
However, there is considerable research to guide us in performing comprehensive evaluations and selecting targeted
treatments for children with ASD. The goal of the present study is to create a manual that combines the best of the available
research to guide the practitioner in the evaluation and treatment selection for children with ASD. The goals of the manual are
threefold:
1. To clarify what a comprehensive ASD evaluation looks like
2. To link assessment results to severity level on the ASD spectrum as laid out by DSM-5, and
3. To provide treatment options best suited for different placements upon the spectrum

  • Autism: Pharmaceutical Trails and Advancements & Case Report
Location: 2

Chair

Marwa Ibrahim Khalil

National Research Centre, Egypt

Session Introduction

Alok Sharma

Neuro Gen Brain & Spine Institute, India

Title: Clinical results of Stem Cell Therapy in Autism

Time : 14:10-14:40

Speaker
Biography:

Alok Sharma is a Neurosurgeon and presently Professor & Head of Department of Neurosurgery at the LTMG Hospital & LTM Medical College, Director of the
NeuroGen Brain & Spine Institute and Consultant Neurosurgeon at the Fortis Hospital in Mumbai , India. He has authored 12 books, edited 2 books, contributed
chapters to 8 other books and has 83 scientifi c publications in medical journals. He has made 146 scientifi c presentations all over the world & has conducted
several national and international trials and has been conferred with numerous honors and awards in his distinguished career. He has organized many international
and national conferences and regularly conducts handson training workshops on Microvascular Surgery, Neuroendoscopy and Spinal fi xations. He has been
committed to both basic as well as clinical research in attempting to fi nd an answer to the problems of paralysis and neurological defi cits that occur following injury
and diseases of the nervous system. Is the pioneer of Stem cell therapy in India and has setup the Stem cell and Genetic research laboratory at the LTMG hospital
& LTM Medical College. He has also created the NeuroGen Brain and Spine institute which is India’s fi rst dedicated Stem Cell Therapy and Neurorehabilitation
Hospital. He has published pathbreaking results of Stem Cell therapy in Pediatric Neurodevelopmental disorders such as Autism and Cerebral palsy as well as in
other conditions such as Muscular dystrophy and Spinal cord injury. He is the founder of the “Indian Journal of Stem Cell Therapy” and on the editorial board of
4 other journals. He is the Founding President of the “Stem Cell Society of India” and the Vice President of the “International Association of Neurorestoratology”.
His other special interests include Revascularization surgery for cerebral ischemia, Psychosurgery, Stereotactic surgery, Neuroendoscopy, Spinal surgery and
Neurotrauma.

Abstract:

An alarming rise in the incidence of ASD and the no availability of definitive treatments for the same have made the need
for investigating new therapeutic strategies the need of the hour. Pre-clinical and clinical research has shown a promising
outcome of cellular therapy such as stem cell therapy in various incurable neurological disorders. Bone marrow stem cells
have unique ability of self-renewal and differentiation. Their paracrine activities such as immunomodulation, neuroprotection
and neurogenesis make them an attractive therapeutic option for ASD. To study the effect of stem cell therapy in autism, a
study was conducted on 149 cases of autism. They were administered autologous bone marrow mononuclear cells (BMMNCs)
intrathecally and were given a personalized multidisciplinary neurorehabilitation program after the cellular therapy. The mean
follow up period of the study was 19 months ± 1 month. It was observed that overall 134 (90%) out of 149 cases showed
improvement. Symptomatically, 122 (81.87%) showed improvement in eye contact, 114 (77%) in attention, 107 (71.81%) in
hyperactivity, 86 (57.71%) in social interaction, 74 (49.66%) in communication, 71 (47.65%) in stereotypical behavior, 69
(46%) in speech and aggressiveness and 51 (34.22%) in self-stimulation. No major irreversible adverse events were recorded
after the intervention. PET CT scan brain was used to monitor the effect of autologous BMMNCs in autism at a cellular
level. On comparing the PET CT scan performed before and 6 months after the intervention, it was observed that FDG
uptake was increased in the previously hypometabolic areas (blue; mesial temporal, cerebellar regions) and reduced in the
previously hypermetabolic areas (red; frontal, parietal regions) and exhibiting a balancing effect to achieve normalization
of brain metabolism. This study opens a new therapeutic avenue for ASD by demonstrating the positive effect of autologous
BMMNCs on clinical symptomatology and objective evidence of neuroimaging.

Biography:

Liang Dandan has completed her PhD from Shanghai International Studies University and Post-doctoral studies from Nanjing Normal University. She is a Professor
and PhD Supervisor of Nanjing Normal University, Department of Chinese Language and Culture. She has published more than 10 papers in reputed journals and
has been serving as an anonymous Reviewer of several journals.

Abstract:

An important difference between spoken language and written language is that spoken language carries prosodic information.
Previous studies revealed that prosody is an important factor in spoken emotional understanding and expression,
especially when the emotion of speech contents is not clear. Autistics tend to speak with flat tone, like parrot and machine.
Recent studies suggest that abnormal prosody is a core disorder in autistic social communication. Therefore, to explore the
recognition mechanism of emotional prosody in autistics is needed, while there is little evidence from Mandarin-speaking
children with autism. This paper investigated the ability of Mandarin-speaking children with high-functioning autism (HFA)
to recognize the four emotions of happiness, anger, sadness and fear under spontaneous emotion conditions and reinforced
emotion conditions using an emotion auditory recognizing task. It was found that under spontaneous emotion conditions,
the recognition accuracy for the four emotions of children with HFA were significantly lower than that of typically developing
(TD) children, indicating overall impairment in autistic children. And under reinforced conditions, significant difference was
manifested in the mechanism of emotion recognition between children with HFA and TD children. Similar to TD children,
children with HFA exhibited stronger ability to recognize anger with reinforced emotion. But unlike TD children, children
with HFA had difficulty recognizing changes in the activation of sadness and fear, and with increase in intensity of emotion,
autistic children had difficulty recognizing acoustic cues correlated with the valence of happiness.

Biography:

Feyereisen is a 25 year veteran of the healthcare industry, serving as CIO in the insurance, provider, and data communities. He has been a pioneer in cloud
computing, security, and biomedical device integration, as well as a featured keynote speaker regarding population health and healthcare analytics. He has been
involved in over 60 patents, and his technologies have been featured in numerous videos, newsletters and magazines, including the cover of Time Magazine. He
currently serves as CEO of Reach IPS, one of the nation’s foremost experts on behavioral health and technology integration.

Abstract:

Despite advances in healthcare EMR’s and analytics, the industry is continuing to leave patients with behavioral and
learning disabilities behind. Federal, state and organizational subsidies have led to greater predictive prognoses for acute
and chronic patients, but such continuity of care lags for behavioral patients, particularly those with autism. Now the evolution
of enhanced application integration technologies combined with affordable biomedical devices helps makes holistic care a
reality. Therapists, pediatricians, special educators, parents and state/insurance systems can collaboratively participate and
track treatment care without the installation of separate software or new learning curves. Devices such as FitBits, children’s
GPS bracelets, electronic patches and “wired” clothing can safely and securely be integrated into a complete information
network accessible by approved care givers that can also contribute as part of a documented treatment plan for those patients.
With this technology, not only can new avenues of care be realized, but there are also significant private, state and federal
monies available to subsidize this move. This speech will demonstrate how technology can become an integral part of the
community of support for an autistic patient and provide many of the tools necessary to move that patient into a more selfreliant
and socially-integrated citizen.

Dimitra Grammatikou

Instituto Tecnologico y de Estudios Superiores de Monterrey, USA

Title: Methods for evaluating the social intervention in robots for children with ASD

Time : 16:00-16:30

Biography:

Dimitra Grammatikou has an MA from Universidad Anahuac and an MA form Lancaster University. She has given therapy to children with ASD for the last 10 years.
The research area she is interested in is in the employment of advanced technology, and more specifically robotics in the treatment of children with ASD.

Abstract:

Technology provides novel alternatives for social intervention for children with ASD. There have been many studies
investigating the role of robots in the therapy of children with ASD, however there has not been documented in a clear
manner the best way to measure the social progress when robots are implemented in a social therapy. Therefore, this study
investigates several methods that can measure the social progress in children with ASD during a social interaction with robots.
Experimental results are presented in order to show the advantages and drawbacks of each evaluation method. Thus, a robot
with facial expressions is evaluated during the social intervention, recognizing that the ultimate goal of the interaction with the
robot is the generalization of the basic social skills such as greeting or the recognition of facial expressions. Potential benefits
and limitations of the measured methods are discussed to give correct feedback and to adjust the robot in a social intervention.