Biography
Biography: Nagwa Abdel Meguid
Abstract
ASD develops through a complex set of etiologies that involve environmental, genetic, and immunological factors. The subjectivity of behavioral diagnosis urges the need for biomarker clinical tests to improve and complement ASD diagnosis. A wide range of biomarkers to diagnose and indicate the severity of ASD include metabolic and genetic biomarkers. The role of oxidative stress in the etiology of an ASD diagnosis, including increased lipid peroxidation, altered antioxidant enzymes in plasma, mitochondrial dysfunction, and the genetic factors; recently reported,as tracking biomarkers will be discussed. However, it is still premature to consider these genetic variants as true biomarkers for ASD, due to their regional-specific nature. The panel addresses two principle categories; molecular with recent gene discoveries and analyze the transcriptional profile of genes involved in the oxidative stress pathway in autism, in addition to relationship between oxidative stress related blood, urine and nutritional biomarkers. Herein, we will comprehensively review the biomarkers reported in ASD in addition to our own experience. It is important to establish those biomarkers resulting able to help diagnosis and optimize the treatment of ASD.